BIOAVAILABILITY OF LSC® MICROCAPS SODIUM BUTYRATE
To best perform its functions – including balancing the intestinal microbiota and exert an eutrophic effect on the colon mucosa with consequent anti-inflammatory effects – it is preferable that butyric acid is in the form linked to sodium due to its high lipophilicity and cell exchange capacity.
Sodium butyrate is a very active molecule but with a high degree of dissociation (pKa 4.82), which in the absence of adequate protection would not reach the intestine, in particular the colon / rectum.
This table shows how LSC® Microcaps Sodium Butyrate overcomes the gastric barrier reaching the intestinal absorption zones (represented by the transition between steps T1 and T2), differently from other types of protection in which Sodium Butyrate is destroyed in the first digestive step, not being bioavailable for the absorption function.
| STEP | Conc.% Of active substance UNDIGESTED SODIUM BUTYRATE LSC® MICROCAPS | Conc.% of active substance UNPROTECTED SODIUM BUTYRATE |
|---|---|---|
| T0 | 100 | 100 |
| T1 | 87 | 3 |
| T2 | 15 | 0 |
| T3 | 1.2 | 0 |
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Credits: Smart Mix